Tracking Cathie Wood: ARK Invest significantly increased its stake in gene-editing company NTLA by over 420,000 shares, while trimming positions across multiple tech and defensive sectors to rebalance the portfolio

All three major U.S. indices closed lower on Thursday. The S&P 500 fell 0.18% to close at 7,709.96, the Nasdaq edged down 0.06% to 26,348.35, and the Dow Jones Industrial Average declined more significantly, dropping 0.85% to 53,885.10. The broader market showed mild correction patterns, with blue-chip stocks under notable pressure.

Amid market volatility, Cathie Wood’s trading activity that day reflected a clear 'aggressive buying + multi-point trimming for rebalancing' strategy—likely taking advantage of the market pullback to selectively add to long-term disruptive innovation holdings while optimizing allocations in overvalued or non-core positions.

Buying focus: Targeting precision medicine and tech infrastructure to position for long-term disruptive opportunities

$Intellia Therapeutics (NTLA.US)$ Purchased an additional 422,198 shares on the day—the largest single buying action. Intellia is a leader in in vivo gene-editing therapies, and its CRISPR technology platform continues to advance clinical trials across multiple rare disease indications, aligning closely with ARK’s core thesis on the long-term disruptive potential of precision medicine. Such a significant increase likely reflects ARK’s view that current valuations present an attractive entry window.

$Block (XYZ.US)$ Added 267,676 shares, marking the second-largest purchase of the day. Block’s Cash App and Square continue to deepen their penetration into the fintech ecosystem, establishing strong competitive moats in decentralized finance and payment innovation. ARK’s increased position likely reflects optimism about its long-term growth potential in financial inclusion and Bitcoin-related businesses.

$Schrodinger (SDGR.US)$ Added 48,584 shares. Schrödinger deeply integrates computational physics with machine learning to accelerate drug discovery and materials science research, making it a representative name in AI-driven life sciences and likely aligned with ARK’s investment logic in the convergence of AI and biotechnology.

$GeneDx Holdings (WGS.US)$ Added 32,194 shares. GeneDx specializes in whole-exome and whole-genome sequencing and has built unique data advantages in rare disease diagnostics, potentially positioning it as a key player in the commercialization of genomics—an area ARK may view as critical to real-world implementation.

$SpaceX (SPCX.US)$ Added 20,318 shares. SpaceX, the undisputed leader in private space exploration, continues to achieve breakthroughs in Starship development and Starlink commercialization. ARK’s long-standing bullish stance on the space economy likely underpins this latest purchase.

$Datadog (DDOG.US)$ Added 14,277 shares. Datadog continues to expand its market share in cloud observability and AI-powered IT operations monitoring. Its platform stickiness and cross-selling capabilities across multiple products create a strong moat, possibly leading ARK to view it as a key component of AI infrastructure investments.

$Cerebras Systems (CBRS.US)$ Added 7,435 shares. Cerebras focuses on developing ultra-large-scale AI chips, and its wafer-scale engine architecture offers differentiated advantages in large model training scenarios—aligning well with ARK’s investment thesis on foundational revolutions in AI computing power.

$MercadoLibre (MELI.US)$ Added 2,399 shares. MercadoLibre has deeply embedded itself in Latin American e-commerce and digital payments, and amid emerging market trends of consumer upgrading and financial inclusion, ARK may see it as a platform asset with strong long-term compounding growth potential.

Selling side: Multiple reductions, suggesting portfolio rebalancing and capital reallocation toward core thematic positions.

$AtaiBeckley (ATAI.US)$ Reduced holdings by 516,184 shares—the largest selling activity of the day. ATAI focuses on innovative mental health therapies, and ARK’s significant reduction may relate to managing concentration risk in individual biotech names or reflect a strategic reallocation of capital toward assets with stronger near-term catalysts.

$Shopify (SHOP.US)$ Sold down 117,172 shares. As a leading e-commerce SaaS company, Shopify has recently shown strong stock performance. ARK’s reduction in holdings likely represents a portfolio rebalancing move—reallocating capital to disruptive innovation names it views as having greater upside potential—rather than a fundamental shift in its view of Shopify’s fundamentals.

$Roblox (RBLX.US)$ Sold down 65,036 shares. Roblox continues to invest heavily in the metaverse and user-generated content platform space. ARK’s reduction in this position may reflect a cautious near-term assessment of its monetization pace, rather than a rejection of its long-term investment thesis.

$Bullish (BLSH.US)$ Sold down 39,509 shares. Bullish is a compliant cryptocurrency exchange. ARK’s modest reduction in this holding may be linked to recent volatility in crypto markets and evolving regulatory conditions, representing routine risk management.

$Iridium Communications (IRDM.US)$ Sold down 28,661 shares. Although Iridium maintains a stable business model in low-Earth orbit satellite communications, ARK’s sale may reflect a structural reallocation within its space-related assets, shifting more resources toward names with higher disruptive growth potential.

$Palantir (PLTR.US)$ Sold down 23,907 shares. Palantir has recently delivered strong results in AI-driven government and enterprise data analytics. ARK’s reduction likely reflects disciplined position sizing amid elevated valuations, aimed at managing concentration risk in individual holdings.

$CrowdStrike (CRWD.US)$ Sold down 13,165 shares. CrowdStrike maintains industry-leading competitive advantages in cloud cybersecurity. ARK’s position reduction is likely part of a structural adjustment across its broader cybersecurity allocation, with capital potentially redirected toward names better aligned with current thematic priorities.

$Cloudflare (NET.US)$ Sold down 9,539 shares. Cloudflare holds significant technological advantages in edge computing and cybersecurity infrastructure. ARK’s minor reduction appears to be a routine liquidity management action within its overall portfolio.

$Brera Holdings (SLMT.US)$ Sold down 5,356 shares,$Elbit Systems (ESLT.US)$ Sold down 2,283 shares,$Strata Critical Medical (SRTA.US)$ Sold down 1,681 shares. The above three positions involved relatively small reductions, likely representing minor portfolio adjustments or routine trimming of non-core holdings during portfolio optimization.

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