On Wednesday (April 29), the three major U.S. stock indices closed mixed, with the Dow Jones Industrial Average falling for the fifth consecutive day. By the close, the Dow Jones Industrial Average dropped 0.57% to 48,861.81 points; the S&P 500 Index fell 0.04% to 7,135.95 points; and the Nasdaq Composite Index rose 0.04% to 24,673.24 points.
Looking at the portfolio adjustments on April 29, 'Wood姐's trading strategy was highly aggressive, reallocating funds across different sectors, sending a strong strategic signal.

Buying direction: Adding positions in Robinhood on dips
The buying side that day showed an extreme 'barbell' strategy: heavily betting on the underlying code of life sciences at one end, and precisely positioning at the traffic entry point of the next-generation financial trading at the other.
Among the moves, 'Wood姐' swept up 553,900 shares overnight. $Robinhood (HOOD.US)$ On the news front, Robinhood’s Q1 earnings report fell short of Wall Street expectations, with a sharp drop in cryptocurrency trading revenue dragging down overall performance. A decline in trading activity exacerbated pressure. Robinhood’s Q1 earnings report disappointed the market significantly, with its share price dropping over 13%, bringing its year-to-date loss to 37%.
Her single-day acquisition of $Intellia Therapeutics (NTLA.US)$ 2.4074 million shares indicates ARK’s absolute faith in NTLA’s (a leader in in vivo gene editing) technological breakthroughs and clinical pipeline progress. After a long period of valuation digestion in the healthcare sector, 'Wood姐' is using real money to declare: the 'batting zone' for gene editing has arrived, and companies capable of rewriting the underlying instructions of life will undoubtedly enjoy non-linear valuation premiums in the future.
In addition, she increased her stake in advanced defense and drone networks. $Kratos Defense & Security Solutions (KTOS.US)$ Against the backdrop of intensifying global geopolitical competition, Kratos, as a leader in military drones and space communication equipment, perfectly aligns with ARK’s investment logic in 'aerospace and advanced defense.' This increase further solidifies its footprint in hardcore physical-world technologies.
Sell-side action: Reducing positions in ARKB and TWST
The sell-side operations were equally decisive, with the core logic summarized in four words: 'Take profits, rotate positions.'
Cathie Wood reduced her holdings in the Bitcoin ETF issued by her firm overnight $ARK 21Shares Bitcoin ETF (ARKB.US)$ A total of 243,100 shares. Combined with the aggressive buying of Robinhood on the buy-side, this is a textbook-level 'capital rotation.' Cathie Wood is not bearish on the crypto market but is choosing to take profits on direct holdings of the underlying asset (ARKB) during Bitcoin's high volatility period and redirect liquidity to cryptocurrency ecosystem trading platforms and infrastructure. This 'picks and shovels strategy' not only mitigates the risk of sharp asset price fluctuations but also allows continued benefit from increased trading volumes.
Previously, she also sold shares of a synthetic biology company $Twist Bioscience (TWST.US)$ 63,000 shares. Compared to the frenzied purchase of 2.4 million shares of NTLA on the buy-side, this sale of 60,000 shares appears ruthless. This reaffirms that ARK is enforcing strict 'keep the strong, cut the weak' discipline amid fierce competition in the healthcare sector, focusing limited capital on the highest-conviction core leaders (such as gene editing).

Risk Disclaimer: The above content only represents the author's view. It does not represent any position or investment advice of Futu. Futu makes no representation or warranty.Read more
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